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Study identifier: NCT06819878 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

A Study to Assess the Efficacy and Safety of Induction and Maintenance Therapy With Afimkibart (RO7790121) in Participants With Moderately to Severely Active Crohn's Disease

Condition: Moderately to Severely Active Crohns Disease  ·  Sponsor: Hoffmann-La Roche

PhasePhase 3
Planned participants600
Who can joinAll sexes, 16 Years to 80 Years
Healthy volunteersNo

About this study

This Phase III, multicenter, double-blind, placebo-controlled treat-through study will evaluate the efficacy and safety of induction and maintenance therapy with Afimkibart (also known as RO7790121) in participants with moderately to severely active Crohn's disease (CD).

This description comes directly from the study's public registry record.

Talk to the study team

Reference Study ID Number: GA45331 https://forpatients.roche.com/ No attachments to email below.  ·  888-662-6728 (U.S. and Canada)  ·  global-roche-genentech-trials@gene.com

Fastest response: use the inquiry form. https://www.gene.com/contact-us/submit-medical-inquiry

Always discuss trial participation with your own doctor first.

Locations (372)

Digestive Health Specialists of the Southeast (Gastroenterology Associates of Dothan) - DothanDothan, Alabama, United StatesRecruiting
Mayo Clinic HospitalPhoenix, Arizona, United StatesRecruiting
Arizona Digestive Health, P.C (ADH)Sun City, Arizona, United StatesRecruiting
University of Arizona-CATS Research CenterTucson, Arizona, United StatesRecruiting
Valley View Internal MedicineGarden Grove, California, United StatesRecruiting
310 Clinical ResearchInglewood, California, United StatesRecruiting
UCSD Medical CenterLa Jolla, California, United StatesRecruiting
Gastro Care AssociatesLancaster, California, United StatesRecruiting
Om Research LLCLancaster, California, United StatesRecruiting
United GastroenterologistsLos Alamitos, California, United StatesRecruiting
Acclaim Clinical Research, Inc.San Diego, California, United StatesRecruiting
Kaiser PermanenteSan Francisco, California, United StatesRecruiting

+ 360 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT06819878