Condition: Glioma · Sponsor: The Third Affiliated hospital of Zhejiang Chinese Medical University
Gliomas are the most common type of primary brain tumors, with the main treatment modalities including surgery, radiotherapy, and chemotherapy. However, gliomas are highly prone to recurrence, posing significant treatment challenges, especially for high-grade gliomas, which have a 5-year survival rate of only 5.5%. Paclitaxel (PTX) is a common chemotherapeutic agent, and its in vitro antitumor efficacy is 1400 times stronger than that of temozolomide (the first-line chemotherapy drug for gliomas). However, due to its large molecular weight (approximately 893 Da), it cannot cross the blood-brain barrier (BBB), preventing its use as a first-line treatment for gliomas. Preliminary research by our team has demonstrated that Specific Mode Electroacupuncture Stimulation (SMES) can open the BBB, increasing the concentration of PTX in tumor tissues, peritumoral tissues, and surrounding invasive tissues, thereby exerting antitumor effects. Therefore, this study aims to preliminarily observe the safety and efficacy of SMES combined with PTX in treating patients with postoperative recurrent high-grade gliomas.
This description comes directly from the study's public registry record.
Xianming Lin PHD · +86-13858028101 · linxianming1966@163.com
Zhaoxing Jia, PHD · +86-18356130598 · zhenxinzhenyi183@163.com
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| The Third Affiliated Hospital of Zhejiang Chinese Medical University | China, Hangzhou City, Zhejiang Province, China | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06818331