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Study identifier: NCT06816134 Synced from ClinicalTrials.gov · July 29, 2026
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Study on the Efficacy and Safety of the TmBU Conditioning Regimen in High-risk or Relapsed/Refractory Acute Leukemia

Condition: Acute Myeloid Leukemia · Acute Lymphoblastic Leukemia · Transplantation, Stem Cell  ·  Sponsor: The First Affiliated Hospital of Soochow University

PhasePhase 2
Planned participants48
Who can joinAll sexes, 15 Years to 65 Years
Healthy volunteersNo

About this study

This project is a prospective, single-center, randomized controlled clinical study. The subjects were high-risk or relapsed/refractory AML or ALL patients aged ≤ 65 years diagnosed by bone marrow cell morphology, immunology, genetics and therapeutic efficacy evaluation. The TmBU scheme or modified Bu/Cy (mBuCy) scheme was used for pretreatment in allo-HSCT. The primary endpoint of the study was the 2-year cumulative incidence of relapse (CIR) after allo-HSCT, and the secondary endpoints were 2-year overall survival rate (OS), progressing-free survival rate (PFS), non-relapse mortality rate (NRM), graft-versus-host disease (GVHD)-free relapse-free survival (GRFS) rate.

This description comes directly from the study's public registry record.

Talk to the study team

Sheng-Li Xue, M.D.  ·  008651267781139  ·  slxue@suda.edu.cn

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Locations (1)

The First Affiliated Hospital of Soochow UniversitySuzhou, Jiangsu, ChinaRecruiting

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Source record: clinicaltrials.gov/study/NCT06816134