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Study identifier: NCT06812715 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Clonal Dynamics of Chronic Lymphocytic Leukaemia Treated With Pirtobrutinib After Previous Treatment With Zanubrutinib

Condition: Chronic Lymphocytic Leukemia  ·  Sponsor: Peter MacCallum Cancer Centre, Australia

PhasePhase 2
Planned participants40
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This is a multicentre single-arm prospective phase II trial evaluating pirtobrutinib in the treatment of relapsed/refractory (R/R) Chronic Lymphocytic Leukaemia (CLL) patients who have previously received zanubrutinib, and to specifically evaluate Bruton Tyrosine Kinase (BTK) mutational status (clonal dynamics) before, during and after treatment with pirtobrutinib.

This description comes directly from the study's public registry record.

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Contact details are listed per location below or on the registry record.

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Locations (3)

Peter MacCallum Cancer CentreMelbourne, Victoria, AustraliaRecruiting
Alfred HospitalMelbourne, Victoria, AustraliaNot Yet Recruiting
Monash Medical CentreMelbourne, Victoria, AustraliaNot Yet Recruiting

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Source record: clinicaltrials.gov/study/NCT06812715