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Study identifier: NCT06810934 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

A Phase 1/2A, Randomized Study of a T Follicular Helper (TFH)-Targeting Genetic Vaccine Strategy Designed to Induce Broad, Durable Immune Responses

Condition: COVID-19 · SARS-CoV-2 Infection  ·  Sponsor: Kara Chew

PhasePhase 1/Phase 2
Planned participants80
Who can joinAll sexes, 40 Years to 64 Years
Healthy volunteersYes

About this study

The goal of this clinical trial is to test two investigational COVID-19 booster vaccines, called CoTend-s3BXBB and CoTend-BXBB, in healthy volunteers ages 40-64. The CoTend-s3BXBB vaccine includes a component called "s3", which was designed to improve the body's response to the vaccine. CoTend-BXBB is the same vaccine without s3. The main questions the study aims to answer are: 1) Is the investigational vaccine safe? 2) Does "s3" lead to bigger, broader, and longer-lasting responses to the vaccine? 5 different doses of the vaccines will be studied. Participants will receive a single dose of either CoTend-s3BXBB, CoTend-BXBB, or placebo. Participants will be monitored for side effects. Saliva, nasal, and blood samples will be collected and immune responses to the vaccine will be measured.

This description comes directly from the study's public registry record.

Talk to the study team

Kara Chew, MD, MS  ·  310-825-0796  ·  kchew@mednet.ucla.edu

Stephanie Buchbinder, MPH  ·  310-825-5147  ·  SBuchbinder@mednet.ucla.edu

Always discuss trial participation with your own doctor first.

Locations (2)

UCLA WestwoodLos Angeles, California, United StatesRecruiting
UCSF Community and Clinical Research CenterSan Francisco, California, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT06810934