Condition: Haemophilia · Hemophilia A · Hemophilia B · Sponsor: Van Creveldkliniek
There is cumulating evidence for the presence of non-observed or subclinical joint bleeding in patients with haemophilia. Early detection of active subclinical synovial proliferation would allow early intervention in order to prevent deterioration of joint health. Patients with subclinical (=non-observed) signs of synovial proliferation in knee(s), ankle(s) and/or elbow(s) will be invited to participate in this study to further characterize the synovial proliferation status (active or inactive) by means of physical examination, MRI, ultrasound and elastography. Synovial proliferation status will be monitored for a maximum period of 12 weeks, during which participants will also receive standard-of-care treatment, i.e. administration of optimized coagulation factor replacement therapy and prescription of the NSAID celecoxib (optional).
This description comes directly from the study's public registry record.
Lize van Vulpen, MD, PhD · +31887558450 · l.f.d.vanvulpen-2@umcutrecht.nl
Merel Timmer, PhD · m.a.timmer@umcutrecht.nl
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| University Medical Center Utrecht | Utrecht, Netherlands | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06809972