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Study identifier: NCT06806579 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Atezolizumab-bevacizumab and Other Immunotherapies: Real-life Experience for Treatment of Hepatocellular Carcinoma

Condition: Hepatocellular Carcinoma (HCC)  ·  Sponsor: IRCCS Azienda Ospedaliero-Universitaria di Bologna

PhaseN/A
Planned participants1000
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

\- Background Hepatocellular carcinoma (HCC), is the fifth most common cancer worldwide and the third leading cause of cancer-related death. In most cases (about 80%), HCC develops in a cirrhotic liver - a condition where the liver has been damaged over time, leading to scarring. This makes treatment more challenging. This study will gather and analyze data from patients treated in real-world settings to: 1. Understand the effectiveness and safety of new treatment combinations (e.g., atezolizumab-bevacizumab and durvalumab-tremelimumab). Identify the best treatment sequences for patients with advanced liver cancer. 2. Discover clinical and laboratory markers that predict treatment responses, helping personalize care and optimize outcomes. By addressing these questions, this study will provide valuable information to healthcare providers and guide future treatment decisions for patients with liver cancer.

This description comes directly from the study's public registry record.

Talk to the study team

Francesco Tovoli, MD  ·  +390512142214  ·  francesco.tovoli@unibo.it

Always discuss trial participation with your own doctor first.

Locations (24)

Ospedali Riuniti Ancona, Via Conca, 71, 60126 Torrette ANTorrette, AN, ItalyRecruiting
I.R.C.C.S. "S. De Bellis", Via Turi, 27, 70013 Castellana Grotte BACastellana Grotte, BA, ItalyNot Yet Recruiting
AUSL Bologna Via Castiglione 15 40136 Bologna BOBologna, BO, ItalyRecruiting
IRCCS Azienda Ospedaliero-Universitaria di Bologna (Oncology Unit), Bologna, BO 40136Bologna, BO, ItalyRecruiting
IRCCS Azienda Ospedaliero-Universitaria di Bologna (Semiotics Unit)Bologna, BO, ItalyRecruiting
IRCCS Azienda Ospedaliero-Universitaria di BolognaBologna, BO, ItalyRecruiting
Azienda Ospedaliera di Rilievo Nazionale e di Alta Specializzazione "Garibaldi, Piazza Santa Maria di Gesù, 5, 95123 Catania CTCatania, CT, ItalyNot Yet Recruiting
Ospedali Riuniti. Viale Pinto Luigi, 1, 71122 Foggia FG.Foggia, FG, ItalyRecruiting
Ospedali Riuniti. Viale Pinto Luigi, 1, 71122 Foggia FGFoggia, FG, ItalyNot Yet Recruiting
AOU Careggi. Largo G. Alessandro Brambilla, 3. 50134 Firenze FIFlorence, FI, ItalyRecruiting
Policlinico di Modena Via del Pozzo, 71, 41125 Modena MOModena, Missouri, ItalyNot Yet Recruiting
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico. via Francesco Sforza, 28 - 20122 Milano.Milan, MI, ItalyRecruiting

+ 12 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT06806579