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Study identifier: NCT06806033 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

A Study to Evaluate the Optimization of the Cytokine Release Syndrome Profile for Glofitamab in Combination With Gemcitabine Plus Oxaliplatin in Participants With Relapsed/Refractory Aggressive B-Cell Non-Hodgkin's Lymphoma

Condition: B-Cell Non-Hodgkins Lymphoma  ·  Sponsor: Hoffmann-La Roche

PhasePhase 2
Planned participants100
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This Phase II trial evaluates the optimization of the cytokine release syndrome (CRS) profile for glofitamab in combination with gemcitabine and oxaliplatin (Glofit-GemOx) in participants with relapsed or refractory aggressive B-cell Non-Hodgkin's lymphoma. The study utilizes an optimized steroid premedication regimen and monitoring schedule specifically designed to enable the administration of the treatment regimen in an outpatient setting.

This description comes directly from the study's public registry record.

Talk to the study team

Reference Study ID Number: GO45434 https://forpatients.roche.com/ No email attachments.  ·  888-662-6728  ·  global-roche-genentech-trials@gene.com

Fastest response: use the inquiry form. https://www.gene.com/contact-us/submit-medical-inquiry

Always discuss trial participation with your own doctor first.

Locations (53)

Alaska Oncology & Hematology, LLCAnchorage, Alaska, United StatesRecruiting
Community Cancer Institute (CCI)Clovis, California, United StatesRecruiting
Providence Medical FoundationFullerton, California, United StatesRecruiting
Los Angeles Cancer NetworkGlendale, California, United StatesRecruiting
Valkyrie Clinical TrialsLos Angeles, California, United StatesRecruiting
Valkyrie Clinical TrialsPanorama City, California, United StatesRecruiting
Zuckerberg San Francisco General HospitalSan Francisco, California, United StatesRecruiting
The Lundquist Institute for BioMedical Innovation at Harbor-UCLA Medical CenteTorrance, California, United StatesRecruiting
Rocky Mountain Cancer Centers, LLPAurora, Colorado, United StatesRecruiting
North Florida/ South Georgia VA Medical CenterGainesville, Florida, United StatesRecruiting
Mount Sinai Comprehensive Cancer CenterMiami, Florida, United StatesRecruiting
Orlando Health Cancer InstituteOrlando, Florida, United StatesRecruiting

+ 41 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT06806033