Condition: Aneurysmal Subarachnoid Haemorrhage · Delayed Ischemic Neurological Deficit · Sponsor: Fondazione IRCCS San Gerardo dei Tintori
Recent studies state that patients affected by aneurysmal subarachnoid hemorrhage (aSAH) today survive longer because they are treated early. Unfortunately, patients often develop chronic disabling neurological deficits at a rate that is still unacceptable given the progress in the specific treatment of this pathology and the volume of systems of neurological monitoring available to date in Italy. The main cause of unfavorable neurological outcome is delayed cerebral ischemia (DCI), often resulting from symptomatic vasospasm defined as delayed neurological ischemic deficit (DIND). The incidence of DIND is not defined and is difficult to diagnose early as there is no gold standard for identifying it, nor guidelines regarding the most effective treatment. Given these gaps, the primary objective of this study is to describe the incidence of DIND in patients affected by aSAH, collecting information regarding the diagnostic imaging (neurological symptom on clinical examination or alteration on instrumental monitoring). Secondary objectives will be to evaluate the different therapeutic strategies adopted in the different participating centers and compare these strategies to mortality and short- and long-term functional neurological outcome. Furthermore, as there are no data in the literature, the Investigators want to describe the indications, usefulness and intensity of treatment in the aSAH patient in case of monitoring of parenchymal intracranial pressure.
This description comes directly from the study's public registry record.
Giuseppe Citerio, Professor, Head of Department · +390392334316 · giuseppe.citerio@unimib.it
Clinical Research Coordination Office · +390392339583 · ricerca.clinica@irccs-sangerardo.it
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| ASST Papa Giovanni XXIII | Bergamo, BG, Italy | Not Yet Recruiting |
| IRCCS Istituto delle Scienze Neurologiche | Bologna, BO, Italy | Not Yet Recruiting |
| ASST Spedali Civili | Brescia, BS, Italy | Not Yet Recruiting |
| Fondazione Poliambulanza | Brescia, BS, Italy | Not Yet Recruiting |
| ASST Lariana Ospedale Sant'Anna | San Fermo della Battaglia, CO, Italy | Not Yet Recruiting |
| ASST Cremona | Cremona, CR, Italy | Not Yet Recruiting |
| Azienda Ospedaliero-Universitaria Careggi | Florence, FI, Italy | Not Yet Recruiting |
| IRCCS Ospedale Policlinico San Martino | Genova, GE, Italy | Not Yet Recruiting |
| ASST Lecco - Ospedale A. Manzoni | Lecco, LC, Italy | Not Yet Recruiting |
| Fondazione IRCCS San Gerardo dei Tintori | Monza, MB, Italy | Recruiting |
| ASST Ovest Milanese - Ospedale di Legnano | Legnano, MI, Italy | Not Yet Recruiting |
| ASST Fatebenefratelli Sacco | Milan, MI, Italy | Not Yet Recruiting |
+ 21 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT06804421