Condition: Parkinson Disease · Amyotrophic Lateral Sclerosis (ALS) · Frontotemporal Dementia (FTD) · Sponsor: Neuromed IRCCS
Neurodegenerative disorders (NDDs), such as Parkinson¿s disease (PD), Alzheimer¿s disease (AD), Frontotemporal dementia (FTD) and Amyotrophic Lateral Sclerosis (ALS) are characterized by aggregation and intracellular accumulation of misfolded proteins, which are believed to play a key role in synaptic dysfunction and neuronal death. Protein structural complexes in biofluids have been proposed to mirror pathological conditions suggesting their use as biomarkers for NDDs characterized by protein aggregation. In this framework, we plan to: i) collect a large cohort of NDD and prodromal patients and healthy subjects using standardized clinical and genetics procedures; ii) apply a novel method based on genomics, proteomics and bioinformatic analysis to map protein complexes in biofluids; iii) identify novel circulating biomarkers and correlate them to genetic profiling and disease endophenotypes, and; iv) validate the biological properties in human brain tissue and dopaminergic cultures.
This description comes directly from the study's public registry record.
Teresa Esposito, PhD · +39 0865915249 · teresa.esposito@igb.cnr.it
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| IRCCS INM Neuromed | Pozzilli, Italy, Italy | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06803784