Condition: Anesthesia · Surgery With General Anesthesia · Noncardiac Surgery · Sponsor: University of California, San Francisco
Low blood pressure, also known as hypotension, is very common during major surgery under general anesthesia. Prolonged or severe hypotension can lead to complications such as kidney injury after surgery that slow down patient recovery. Anesthesiologists commonly administer medications called vasopressors to treat low blood pressure during surgery. These medications help raise the blood pressure back up to a safe range. Two vasopressor medications are commonly used for this purpose: norepinephrine and phenylephrine. Each of these medications has slightly different effects on the heart and blood vessels (cardiovascular system). It remains unknown which of these standard medications is better for treating low blood pressure during surgery. The goal of this clinical trial is to determine which of these two medications is better at preventing injury to the kidneys after major noncardiac surgery as well as other complications such as heart problems. Major surgeries are defined as those lasting at least two hours under general anesthesia. This trial will randomize about ten centers in North America to use either norepinephrine or phenylephrine as the primary medication to treat low blood pressure in adults undergoing major noncardiac surgery. Each hospital will prioritize one of the drugs each month, and the assigned drug will rotate each month at each hospital. No further participant involvement will be required as de-identified data are collected as part of standard medical care.
This description comes directly from the study's public registry record.
Matthieu Legrand, MD PhD · 415-476-9035 · matthieu.legrand@ucsf.edu
Michael P. Bokoch, MD PhD · 415-476-8389 · michael.bokoch@ucsf.edu
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| University of California, San Francisco | San Francisco, California, United States | Recruiting |
| University of Maryland | College Park, Maryland, United States | Recruiting |
| University of Michigan | Ann Arbor, Michigan, United States | Recruiting |
| Henry Ford Health | Detroit, Michigan, United States | Recruiting |
| Duke University Medical Center | Durham, North Carolina, United States | Recruiting |
| Wake Forest University School of Medicine | Winston-Salem, North Carolina, United States | Recruiting |
| UT Southwestern Medical Center | Dallas, Texas, United States | Recruiting |
| University of Virginia | Charlottesville, Virginia, United States | Recruiting |
| University of Washington | Seattle, Washington, United States | Recruiting |
| University Health Network | Toronto, Ontario, Canada | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06802224