Condition: Non-Small Cell Lung Cancer · Sponsor: University of Maryland, Baltimore
The purpose of this research study is to find out if adding radiation prior to chemoimmunotherapy and surgery is effective for people with non-small cell lung cancer (NSCLC) who have the potential for surgery. Standard of Care Chemoimmunotherapy: For this study, standard of care chemotherapy will be used. This means this is the type of chemotherapy that is normal for your cancer. In addition to the chemotherapy, you will also receive the immunotherapy drug, nivolumab. This will be administered intravenously once every 3 weeks for up to 3 cycles (i.e. 9 weeks of total systemic therapy), prior to surgical resection assessment. This combination is made up of the chemotherapy drugs carboplatin or cisplatin along with pemetrexed, paclitaxel or gemcitabine, and the immunotherapy drug is nivolumab. The chemotherapy is used to kill cancer cells, and the immunotherapy enables your immune system to attack cancer cells. Stereotactic Body Radiation Therapy (SBRT) SBRT is when radiation is delivered at higher doses over a smaller period of time. For this study, you will receive three doses of radiation delivered every other day, for three total days. The final dose of radiation will happen within 7 days of starting chemoimmunotherapy. You will be followed for up to 100 days following your last chemoimmunotherapy dose to monitor for potential side effects. Following this you will continue with your standard follow up with your doctor. During the standard follow-up time, study staff wil…
This description comes directly from the study's public registry record.
Matthew Ferris, MD · 410-328-6080 · matthew.ferris@umm.edu
Caitlin Eggleston, MPH · 410-328-7586 · caitlineggleston@umm.edu
Always discuss trial participation with your own doctor first.
| Maryland Proton Treatment Center | Baltimore, Maryland, United States | Recruiting |
| University of Maryland Greenebaum Cancer Center | Baltimore, Maryland, United States | Recruiting |
| Upper Chesapeake- Kaufman Cancer Center | Bel Air, Maryland, United States | Recruiting |
| Baltimore Washington Medical Center- Tate Cancer Center | Glen Burnie, Maryland, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06800339