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Study identifier: NCT06800209 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Pain Reprocessing Therapy in Post-Operative Knee Pain

Condition: Pain, Chronic · Knee Pain Chronic  ·  Sponsor: University of Colorado, Denver

PhasePhase 2
Planned participants110
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The goal of this clinical trial is to learn whether Pain Reprocessing Therapy (PRT) can help adults with knee pain after knee replacement surgery. The study is comparing PRT to usual care (the regular treatment people get after surgery) to see which works better for relieving pain. The main questions the study aims to answer are: 1. Does PRT help lower pain in people who have chronic knee pain after knee surgery? 2. How do the effects of PRT compare with usual care in terms of pain relief and other factors such as anxiety, depression, and sleep? 3. How does PRT impact the brain? Participants will: 1. Be randomly assigned to receive either PRT or usual care. 2. Complete questionnaires about their pain and health. 3. If in the PRT group, have eight weekly therapy sessions over video calls with a therapist. 4. If interested, may also take part in an optional EEG test to measure brain activity related to pain.

This description comes directly from the study's public registry record.

Talk to the study team

Allina Nocon, PhD  ·  212-774-2572  ·  Complexjoint@hss.edu

Always discuss trial participation with your own doctor first.

Locations (2)

University of Colorado Anschutz Medical CampusAurora, Colorado, United StatesActive Not Recruiting
Hospital for Special SurgeryNew York, New York, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT06800209