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Study identifier: NCT06799013 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Safety and Immunogenicity of a Self-Amplifying RNA Vaccine Against Crimean-Congo Hemorrhagic Fever

Condition: Vaccine · Crimean-Congo Hemorrhagic Fever  ·  Sponsor: HDT Bio

PhasePhase 1
Planned participants48
Who can joinAll sexes, 18 Years to 64 Years
Healthy volunteersYes

About this study

The goal of this clinical trial is to assess the safety, tolerability and immunogenicity of three dosage levels, and a single or two-dose administration regimen, of the investigational HDT-321 product administered intra-muscularly. The main questions it aims to answer are: * Is HDT-321 safe to use * Does HDT-321 provide protection against Crimean-Congo hemorrhagic fever virus (CCHFV) Researchers will record any adverse events and test blood samples to see if HDT-321 is safe and works to protect participants against Crimean-Congo hemorrhagic fever virus (CCHFV) Participants will: * Receive 1 or 2 doses of HDT-321 * Complete a memory aid and measurements for 7 days after receiving each dose of HDT-321 * Be followed throughout the study using phone calls and clinic visits to check for and record adverse events * Provide blood samples at specific study visits

This description comes directly from the study's public registry record.

Talk to the study team

James Keary  ·  206-567-8230  ·  james.keary@hdt.bio

Aude Frevol  ·  206-704-5705  ·  aude.frevol@hdt.bio

Always discuss trial participation with your own doctor first.

Locations (1)

Flourish Research San Antonio (Clinical Trials of Texas)San Antonio, Texas, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT06799013