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Study identifier: NCT06798324 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

tDCS Plus Varenicline for Smoking Cessation

Condition: Nicotine Dependence · Tobacco Smoking · Smoking Cessation  ·  Sponsor: Centre for Addiction and Mental Health

PhasePhase 4
Planned participants160
Who can joinAll sexes, 18 Years to 85 Years
Healthy volunteersNo

About this study

The goal of this clinical trial is to determine if active transcranial direct current stimulation (tDCS) plus varenicline is an effective, safe and accessible treatment option for smoking cessation. The main questions this trial aims to answer are: 1. Does active tDCS plus varenicline improve short-term and long-term smoking abstinence rates compared to sham tDCS plus varenicline? 2. Are the safety profiles between active tDCS plus varenicline and sham tDCS plus varenicline different? The tDCS treatment schedule includes 10 daily sessions for the first 2 weeks (M to F), followed by 5 single bi-weekly booster sessions for the remainder of the treatment period. Participants will come in-person for two follow-up sessions to assess smoking behaviour at 6- and 12-months post-treatment.

This description comes directly from the study's public registry record.

Talk to the study team

Laurie A Zawertailo, PhD  ·  416-535-8501  ·  laurie.zawertailo@camh.ca

Kameron Iturralde, BSc  ·  416-535-8501  ·  kameron.iturralde@camh.ca

Always discuss trial participation with your own doctor first.

Locations (1)

Centre for Addiction and Mental HealthToronto, Ontario, CanadaRecruiting

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Source record: clinicaltrials.gov/study/NCT06798324