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Study identifier: NCT06797635 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Study of Patritumab Deruxtecan Plus Pembrolizumab With Other Anticancer Agents in Participants With High-Risk Early-Stage Triple-Negative or Hormone Receptor-Low Positive/HER-2 Negative Breast Cancer (MK-1022-010, HERTHENA-Breast-03)

Condition: Breast Neoplasms · Breast Cancer  ·  Sponsor: Merck Sharp & Dohme LLC

PhasePhase 2
Planned participants372
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

Researchers are looking for new ways to treat triple-negative breast cancer (TNBC) and hormone receptor (HR) low positive/human epidermal growth factor receptor-2 (HER2) negative breast cancer. The main goals of this study are to learn: * About the safety of the study treatments and if people tolerate them * If people who receive patritumab deruxtecan, pembrolizumab, and chemotherapy before surgery have fewer cancer cells removed during surgery compared to those who receive only pembrolizumab (pembro) and chemotherapy.

This description comes directly from the study's public registry record.

Talk to the study team

Toll Free Number  ·  1-888-577-8839  ·  Trialsites@msd.com

Always discuss trial participation with your own doctor first.

Locations (17)

UCLA Hematology/Oncology - Parkside ( Site 0021)Santa Monica, California, United StatesRecruiting
Orchard Healthcare Research Inc. ( Site 0006)Skokie, Illinois, United StatesRecruiting
Intermountain Health St. Vincent Regional Hospital - Cancer Centers of Montana ( Site 0003)Billings, Montana, United StatesRecruiting
Northwest Cancer Specialists (Compass Oncology) ( Site 8003)Tigard, Oregon, United StatesRecruiting
SCRI Oncology Partners ( Site 7000)Nashville, Tennessee, United StatesRecruiting
Texas Oncology - DFW ( Site 8000)Dallas, Texas, United StatesRecruiting
Houston Methodist Hospital ( Site 0022)Houston, Texas, United StatesRecruiting
Virginia Oncology Associates (VOA) ( Site 8001)Norfolk, Virginia, United StatesRecruiting
Seoul National University Hospital ( Site 2400)Seoul, South KoreaRecruiting
Severance Hospital, Yonsei University Health System ( Site 2402)Seoul, South KoreaRecruiting
Asan Medical Center ( Site 2401)Seoul, South KoreaRecruiting
Institut Català d'Oncologia (ICO) - Badalona ( Site 1700)Badalona, Catalonia, SpainRecruiting

+ 5 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT06797635