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Study identifier: NCT06797336 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

A Study of PT0253 in Participants With KRAS G12D Mutated Advanced Solid Tumors

Condition: Solid Tumor  ·  Sponsor: PAQ Therapeutics, Inc.

PhasePhase 1
Planned participants115
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The primary purpose of this study is to evaluate the safety and tolerability, determine the maximally tolerated dose (MTD) and/or recommended Phase 2 dose(s) (RP2D) of PT0253 in adult participants with Kirsten rat sarcoma viral oncogene homolog (KRAS) G12D mutated advanced solid tumors as monotherapy.

This description comes directly from the study's public registry record.

Talk to the study team

PAQ Therapeutics  ·  781-819-2949  ·  ClinicalTrials@paqtx.com

Always discuss trial participation with your own doctor first.

Locations (7)

Dana Farber/Massachusetts General Hospital, IncBoston, Massachusetts, United StatesRecruiting
SCRI Lake MaryNashville, Tennessee, United StatesRecruiting
SCRI Oncology PartnersNashville, Tennessee, United StatesRecruiting
New Experimental Therapeutics of San Antonio LLCSan Antonio, Texas, United StatesRecruiting
START - South Texas Accelerated Research Therapeutics, LLCSan Antonio, Texas, United StatesRecruiting
START Mountain RegionWest Valley City, Utah, United StatesRecruiting
NEXT VirginiaFairfax, Virginia, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT06797336