Condition: Adrenomyeloneuropathy Without Cerebral Involvement · Sponsor: Third Military Medical University
Adrenal spinal neuropathy (AMN) is a rare X-linked genetic disease caused by mutations in the ABCD1 gene, and belongs to a special type of adrenal leukodystrophy. The patient's lower limb strength is weakened, the range of motion of the ankle joint is reduced, the hip flexors are weak and affect walking, and the peripheral nerves and vibration sensation are damaged. As the condition worsens, the lower limb muscle tone changes from hyperactivity to decrease, ultimately transitioning from spastic paralysis to flaccid paralysis. At present, the treatment plan for AMN is not yet perfect, and effective therapies are urgently needed to alleviate symptoms. Spinal cord electrical stimulation (SCS) is the implantation of a thin electrode into the epidural space of the corresponding spinal segment within the spinal canal. Then connect the electrodes to a nerve stimulator implanted subcutaneously in the iliac region, and use electrical pulses to stimulate the conduction of sensory neurons in the posterior column and posterior horn of the spinal cord for treatment, which can achieve the goal of controlling pain. In addition, SCS has also conducted research on the recovery of lower limb function in paraplegic patients and upper limb function in post-stroke hemiplegic patients, and has improved corresponding motor dysfunction to a certain extent. Spinal cord stimulation may be a potential treatment for motor dysfunction in AMN. Based on the above, this study attempts to evaluate the effic…
This description comes directly from the study's public registry record.
Liang Tan, Ph,D · 86-158-2354-0630 · tracy200712@hotmail.com
Always discuss trial participation with your own doctor first.
| Beijing TianTan Hospital | Beijing, Beijing Municipality, China | Active Not Recruiting |
| The 958 Hospital of Chinese People's Liberation Army, The Jiangbei Campus of Southwest Hospital, The First Affiliated Hospital of Army Medical University | Chongqing, Chongqing Municipality, China | Recruiting |
| the Southwest hospital | Chongqing, Chongqing Municipality, China | Recruiting |
| Jingmen No.1 People's Hospital | Jingmen, Hubei, China | Active Not Recruiting |
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Source record: clinicaltrials.gov/study/NCT06796920