Condition: Acute Hypoxemic Respiratory Failure · High-Flow Nasal Oxygen Therapy · Noninvasive Ventilation · Sponsor: Southeast University, China
Acute hypoxemic respiratory failure (AHRF) is a common indication for admission to an intensive care unit (ICU), with mortality exceeding 50% in cases where invasive mechanical ventilation is needed. Therefore, assessment of the most adequate oxygen strategy to avoid intubation in patients with AHRF deserves consideration.Previous studies have indicated that non-invasive oxygenation strategies, including high-flow nasal oxygen (HFNO), helmet or face mask noninvasive ventilation (NIV), and continuous positive airway pressure (CPAP), are effective in preventing endotracheal intubation in adult patients with AHRF when compared to the standard oxygen therapy. However, the optimal non-invasive oxygenation strategies remain uncertain. This study aim to determine whether CPAP, compared with HFNC or NIV, increase the intubation-free survival during study period in patients with AHRF.
This description comes directly from the study's public registry record.
Ling Liu, PhD · +8613851435472 · liulingdoctor@126.com
Yi Yang, PhD · +8613913966300 · yiyiyang2004@163.com
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| Zhongda Hospital, School of Medicine, Southeast University | Nanjing, Jiangsu, China | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06795971