Condition: Cardiac Failure · Low Cardiac Output Syndrome · Sponsor: Università Vita-Salute San Raffaele
Chronic mitral regurgitation is the most common valvular abnormality worldwide, it occurs in 10% of the general population and its prevalence increases with age. When left untreated, it can lead to left ventricular dysfunction and cause disabling symptoms (e.g., fatigue and dyspnea), life-threatening complications (e.g., ventricular dilation, congestive heart failure) and death. Surgical correction of chronic mitral regurgitation before irreversible changes happen can be curative. Open surgical valve repair or replacement are accomplished through cardiopulmonary bypass and cardioplegic arrest. Myocardial protection is essential to guarantee an uneventful perioperative course since a not-well protected heart may lead to postoperative low-cardiac output syndrome. This occurs in 30% of high-risk patients who undergo elective cardiac surgery and is associated with 20% mortality. Cardioplegia preserves the heart during ischemic arrest by reducing its metabolic demand. The most effective cardioplegia for protection in adult cardiac surgery remains unknown and improving the protection of the heart during the ischemic arrest may potentially improve patients' postoperative outcomes. Pharmacological adjuvants to the cardioplegic solutions have been tested to mitigate the ischaemic-reperfusion injury following cardiac surgery. Ultra-short acting beta-blockers (e.g., esmolol, landiolol) decrease intraoperative myocardial metabolic demand and suppress the sympathetic response to surgical …
This description comes directly from the study's public registry record.
Fabrizio Monaco, MD · 0226436154 · monaco.fabrizio@hsr.it
Giovanni Landoni, Prof. · 0226436154 · landoni.giovanni@hsr.it
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| Ospedale Cesare Arrigo | Alessandria, Piedmont, Italy | Recruiting |
| A. O. Ordine Mauriziano di Torino | Torino, TO, Italy | Recruiting |
| AOU di Alessandria | Alessandria, Italy | Recruiting |
| Azienda Ospedaliero Universitaria Policlinico "G.Rodolico - San Marco" | Catania, Italy | Recruiting |
| AOU Careggi | Florence, Italy | Recruiting |
| Azienda Ospedaliero Universitaria Ospedali Riuniti di Foggia | Foggia, Italy | Recruiting |
| IRCCS San Martino di Genova | Genova, Italy | Recruiting |
| Ospedale San Raffaele | Milan, Italy | Recruiting |
| ASST Grande Ospedale Metropolitano Niguarda | Milan, Italy | Recruiting |
| AOU Policlinico Paolo Giaccone | Palermo, Italy | Recruiting |
| Azienda Ospedaliero Universitaria Pisana | Pisa, Italy | Recruiting |
| AOR San Carlo | Potenza, Italy | Recruiting |
+ 1 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT06793670