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Study identifier: NCT06793215 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

A Study Evaluating the Efficacy and Safety of Divarasib and Pembrolizumab Versus Pembrolizumab and Pemetrexed and Carboplatin or Cisplatin in Participants With Previously Untreated, KRAS G12C-Mutated, Advanced or Metastatic Non-Squamous Non-Small Cell Lung Cancer

Condition: Non-Small Cell Lung Cancer · KRAS G12C Lung Cancer  ·  Sponsor: Hoffmann-La Roche

PhasePhase 3
Planned participants600
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The purpose of this study is to evaluate the efficacy and safety of divarasib and pembrolizumab compared with pembrolizumab and pemetrexed and carboplatin or cisplatin, for the first-line treatment of adult participants with KRAS G12C-mutated, advanced or metastatic non squamous non-small cell lung cancer (NSCLC).

This description comes directly from the study's public registry record.

Talk to the study team

Reference Study ID Number: CO45042 https://forpatients.roche.com/ No attachments to email below.  ·  888-662-6728 (U.S. and Canada)  ·  global-roche-genentech-trials@gene.com

Fastest response: use the inquiry form. https://www.gene.com/contact-us/submit-medical-inquiry

Always discuss trial participation with your own doctor first.

Locations (260)

Alaska Oncology and HematologyAnchorage, Alaska, United StatesRecruiting
City of Hope - PhoenixGoodyear, Arizona, United StatesRecruiting
Marin Cancer Care IncGreenbrae, California, United StatesRecruiting
Hoag Memorial HospitalNewport Beach, California, United StatesRecruiting
Palo Alto Medical Foundation Research CenterPalo Alto, California, United StatesRecruiting
Sutter Institute for Medical ResearchRoseville, California, United StatesRecruiting
California Pacific Medical CenterSan Francisco, California, United StatesRecruiting
UC Health Oncology ResearchColorado Springs, Colorado, United StatesRecruiting
Poudre Valley Health Care, Inc. d/b/a Poudre Valley Health SystemFort Collins, Colorado, United StatesRecruiting
Hartford HospitalHartford, Connecticut, United StatesRecruiting
Florida Cancer Specialists - SOUTH - SCRI - PPDSFort Myers, Florida, United StatesRecruiting
University of Florida Health at ShandsGainesville, Florida, United StatesRecruiting

+ 248 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT06793215