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Study identifier: NCT06792422 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

A Study Investigating Oral Semaglutide in People with Open-Angle Glaucoma

Condition: Primary Open Angle Glaucoma (POAG) · Open-Angle Glaucoma · Glaucoma  ·  Sponsor: Glostrup University Hospital, Copenhagen

PhasePhase 4
Planned participants126
Who can joinAll sexes, 45 Years to no upper limit
Healthy volunteersNo

About this study

The aim of this clinical trial is to investigate whether oral semaglutide can be used to treat open-angle glaucoma. The main question it aims to answer is: Does oral semaglutide safely improve inner retinal function in patients with open-angle glaucoma as measured by the photopic negative response of the electroretinogram. Researchers will compare oral semaglutide to a placebo (a look-alike substance that contains no drug). Participants will: * Take semaglutide or a placebo every day for 6 months. * Visit the clinic 5 times in total for tests and interviews: At baseline (the first day they are included in the study), after 1 month, after 2 months, after 3 months, and after 6 months (the last day they are included in the study).

This description comes directly from the study's public registry record.

Talk to the study team

Miriam Kolko, MD, PhD  ·  +45 29807667  ·  miriamk@sund.ku.dk

Anna-Sophie Thein  ·  anna-sophie.thein@sund.ku.dk

Always discuss trial participation with your own doctor first.

Locations (1)

Department of Ophthalmology, RigshospitaletGlostrup Municipality, DenmarkRecruiting

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Source record: clinicaltrials.gov/study/NCT06792422