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Study identifier: NCT06792214 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Antiviral Strategies in the Prevention of Long-term Cardiovascular Outcomes Following COVID-19: The paxloviD/Remdesivir Effectiveness For the prEvention of loNg coviD Clinical Trial

Condition: SARS CoV-2 Post-Acute Sequelae  ·  Sponsor: Mount Sinai Hospital, Canada

PhasePhase 4
Planned participants118
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The DEFEND trial will be the world's first clinical trial to study the effectiveness of Paxlovid or Veklury in the prevention of cardiovascular post-acute sequelae of SARS-CoV-2 among hospitalized adults. Additionally, this pilot study will inform the design and conduct of a future full-scale multi-centre trial by testing the feasibility and accuracy of this study design.

This description comes directly from the study's public registry record.

Talk to the study team

Dr. Kieran Quinn  ·  416-843-8403  ·  kieran.quinn@mail.utoronto.ca

Always discuss trial participation with your own doctor first.

Locations (4)

Kingston Health Sciences CentreKingston, Ontario, CanadaNot Yet Recruiting
Niagara Health SystemSt. Catharines, Ontario, CanadaNot Yet Recruiting
Mount Sinai Hospital, Sinai Health SystemToronto, Ontario, CanadaRecruiting
St. Joseph's Health Centre, Unity Health TorontoToronto, Ontario, CanadaNot Yet Recruiting

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Source record: clinicaltrials.gov/study/NCT06792214