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Study identifier: NCT06791915 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Effect of Mechanical Ventilation on Radiofrequency Ablation in Atrial Fibrillation

Condition: Radiofrequency Ablation · Atrial Fibrillation · Mechanical Ventilation  ·  Sponsor: Kocaeli City Hospital

PhaseN/A
Planned participants50
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersYes

About this study

Radiofrequency ablation (RFA) for atrial fibrillation (AF) is performed under general anesthesia. The success of the procedure depends on the safe contact of the catheter electrode with the myocardium. Movement of the catheter tip due to respiratory changes can result in inadequate lesion formation and AF recurrence. The success of AF ablation depends on the adequacy of energy delivered to the myocardium and the durability of pulmonary vein isolation (PVI). Poor energy delivery and tissue heating during ablation are a major cause of procedural failure in RFA. To improve the success of the PVI procedure, efforts are underway to optimize catheter stability and contact force. However, catheter force and stability are influenced by respiration-induced thoracic motion, highlighting the importance of controlled breathing for further optimization. Fluoroscopy and ablation times during electroanatomic mapping-guided AF ablations improved with controlled mechanical ventilation. General anesthesia improved catheter contact. Low tidal volume, high respiratory rate (FCV), pressure controlled mechanical ventilation (PCV), volume controlled mechanical ventilation (VCV), pressure controlled volume assured mechanical ventilation (PRVC) can be used in investigators' hospital. The literature offers no definitive proof that one ablation procedure is superior to another.

This description comes directly from the study's public registry record.

Talk to the study team

Merve Yazici Kara  ·  +90 533 686 0156  ·  merreset@hotmail.com

Nurseda Dundar  ·  +90 530 510 2245  ·  d.nurseda@hotmail.com

Always discuss trial participation with your own doctor first.

Locations (1)

Kocaeli City HospitalKocaeli, Turkey (Türkiye)Recruiting

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Source record: clinicaltrials.gov/study/NCT06791915