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Study identifier: NCT06789445 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

A Study to Investigate the Safety of OpCT-001 in Adults Who Have Primary Photoreceptor Disease (CLARICO)

Condition: Primary Photoreceptor Disease · Retinitis Pigmentosa (RP) · Usher Syndrome  ·  Sponsor: BlueRock Therapeutics

PhasePhase 1/Phase 2
Planned participants54
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

Study OpCT-001-101 is a Phase 1/2a first-in-human, multisite, 2-part interventional study to evaluate the safety, tolerability, and the effect on clinical outcomes of OpCT-001 in approximately 54 adults with primary photoreceptor (PR) disease. Phase 1 focuses on safety and features a dose-escalation design. Phase 2 is designed to gather additional safety data and assess the effect of OpCT-001 on measures of visual function, functional vision, and anatomic measures of engraftment in different clinical subgroups.

This description comes directly from the study's public registry record.

Talk to the study team

Patient Engagement  ·  1-877-380-3931  ·  clinicaltrials@bluerocktx.com

Always discuss trial participation with your own doctor first.

Locations (5)

University of Southern California /Children's Hospital of Los AngelesLos Angeles, California, United StatesRecruiting
University of Miami, Bascom Palmer Eye InstituteMiami, Florida, United StatesRecruiting
Mid Atlantic Retina/ Wills EyePhiladelphia, Pennsylvania, United StatesRecruiting
Retina Foundation of the SouthwestDallas, Texas, United StatesRecruiting
University of WisconsinMadison, Wisconsin, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT06789445