Condition: Percutaneous Coronary Intervention (PCI) · Acute Myocardial Infarction · Angina (Stable) · Sponsor: Instituto de Investigación Sanitaria y Biomédica de Alicante
Endothelial dysfunction is one of the aetiological factors in ischaemic heart disease (IHD). Aerobic exercise is effective in improving endothelial function, as measured by flow-mediated dilation (FMD), in patients with IHD. Within the aerobic exercise methods, there is evidence showing that high-intensity interval training (HIIT) increases FMD to a greater extent than moderate-intensity training (MIT) in these patients. Notably, in a recent review, our research group found that only studies performing long bouts of HIIT (long HIIT: higher than 1 min) found a greater effect on FMD, while no differences were found in those studies using short bouts of HIIT (short HIIT: ≤ 1 min) and MIT. However, no experimental studies comparing the effect of long HIIT, short HIIT, and MIT on endothelial function, as well as other predictors of mortality, such as cardiorespiratory fitness, brain-derived neurotrophic factor (BDNF) levels or parasympathetic branch activity, have been performed. Therefore, the main objective of this project will be to compare the effect of the three aerobic exercise methods on endothelial function, as measured by FMD, in patients with IHD. Complementarily, the effect of aerobic exercise, depending on the exercise method, on different mortality predictors will be compared. For this purpose, a multicentre randomised study will be carried out (2 hospitals in Elche and one in Alicante). Assessors will be blinded to the patients allocation. Participants will be aware …
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Jose Manuel Sarabia, PhD · 965222568 · jsarabia@umh.es
Agustin Manresa Rocamora, PhD · 626542131 · amanresa@umh.es
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| Instituto de Investigación Sanitaria y Biomédica de Alicante | Alicante, Alicante, Spain | Recruiting |
| Centro de Investigación del deporte | Elche, Alicante, Spain | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06788275