Condition: Mixed Neuroendocrine-Non Neuroendocrine Neoplasm · Neuroendocrine Neoplasm · Sponsor: European Institute of Oncology
For GEP mixed neuroendocrine (NE) non-neuroendocrine neoplasms (MiNENs) a key issue affecting prognosis is sometimes the difficulty in obtaining a timely diagnosis, as the NE component is often localized in deeper anatomical locations and/or becomes prevalent over time. The tissue material of biopsies may be not enough to define the NE component when this is particularly small and this could impact on therapeutic decision. Furthermore GEP NENs need to be characterized for potentially druggable biomarkers and liquid biopsy has clear advantage to the solid one to this aim. Here, we will exploit epigenetic differences characterizing NE tumors to build a DNA methylation-based liquid biopsy assay able to detect circulating tumor DNA of NE derivation, to enable the non-invasive diagnosis and monitoring of GEP-MiNENs.
This description comes directly from the study's public registry record.
Nicola Fazio, MD · 0257489258 · divisione.gastrointestinale@ieo.it
Francesca Spada, MD · 0257489258 · divisione.gastrointestinale@ieo.it
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| European Institute of Oncology | Milan, Italy | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06785597