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Study identifier: NCT06782971 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Evaluation of Combined Sensitising and Hypomethylating Therapy Outcomes in AML PDX

Condition: AML - Acute Myeloid Leukemia  ·  Sponsor: Clinical Hub for Interventional Research (CHOIR)

PhaseN/A
Planned participants25
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The goal of this observational study is to develop new ways to test new drug combinations to kill tumour cells, in patients with acute myeloid leukemia (AML). The main questions it aims to answer are: * Are there new ways to speed up discovery of better treatments for AML patients using AML cells from individual from patients in special mice that can accept human tissue? * Do these mice show treatment responses that are similar to the individual AML patient from whom cells were derived? Participants with AML who are taking standard of care treatment of venetoclax and azacitidine will be asked to donate blood and bone marrow samples for this study.

This description comes directly from the study's public registry record.

Talk to the study team

John Pimanda, Professor  ·  +61 000000000  ·  cosmos.jcsmr@anu.edu.au

Mark Polizzotto, Professor  ·  cosmos.jcsmr@anu.edu.au

Always discuss trial participation with your own doctor first.

Locations (4)

Canberra Health ServicesCanberra, Australian Capital Territory, AustraliaRecruiting
Prince of Wales HospitalSydney, New South Wales, AustraliaRecruiting
Royal North Shore HospitalSydney, New South Wales, AustraliaNot Yet Recruiting
Westmead HospitalWestmead, New South Wales, AustraliaRecruiting

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Source record: clinicaltrials.gov/study/NCT06782971