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Study identifier: NCT06780943 Synced from ClinicalTrials.gov · July 29, 2026
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Quantification of Motor Compensation Following Biomechanical, Proprioceptive and Physiological Alterations Post-lower Limb Amputation.

Condition: Amputation  ·  Sponsor: Centre Hospitalier Universitaire de Nīmes

PhaseN/A
Planned participants75
Who can joinAll sexes, 18 Years to 80 Years
Healthy volunteersYes

About this study

Lower limb amputation causes segmental loss that alters locomotor organization. The human body, designed to function in a multisegmental manner, must adapt to this new configuration where segments are missing, depending on the level of amputation. These adaptations are directly linked to the biomechanical, physiological and proprioceptive alterations caused by the loss of the amputated segments. Without mechanoreceptive afferents essential for regulating locomotion, the sensory system uses alternative information to maintain efficient locomotor function. The prosthesis partially compensates, but remains limited on the biomechanical and proprioceptive levels. Current prosthetic technologies, inspired by biomimicry, aim to imitate evolutionary solutions to restore walking, although current algorithms do not allow real-time modulation. This research aims to characterize post-amputation locomotor adaptations through biomechanical, physiological and proprioceptive exploration to develop a "locomotor characterization" model. The study authors hypothesize that the post-amputation alterations are exacerbated in contexts of continuous and discontinuous constraints (e.g., ascent/descent and destabilization), and that the addition of a prosthesis, although inspired by biomimicry, only restores partial compensation of locomotor functions.

This description comes directly from the study's public registry record.

Talk to the study team

Eric Pantera  ·  0466022536  ·  eric.pantera@chu-nimes.fr

Always discuss trial participation with your own doctor first.

Locations (1)

CHU de NîmesNîmes, FranceRecruiting

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Source record: clinicaltrials.gov/study/NCT06780943