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Study identifier: NCT06780670 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Open-label Study Comparing AAA817 Versus Standard of Care in the Treatment of Previously Treated PSMA-positive mCRPC Adults Who Have Disease Progressed on or After [177Lu]Lu-PSMA Targeted Therapy

Condition: Prostate Cancer  ·  Sponsor: Novartis Pharmaceuticals

PhasePhase 2/Phase 3
Planned participants443
Who can joinMale, 18 Years to 100 Years
Healthy volunteersNo

About this study

This is a Phase II/III study. Patient population is adult participants with PSMA-positive mCRPC who had treatments with androgen receptor pathway inhibitor (ARPI) and taxane-based chemotherapy and progressed on or after \[177Lu\]Lu-PSMA targeted therapy. Treatment of interest: the investigational treatment is AAA817 regardless of subsequent anti-neoplastic treatment. The control treatment is investigator's choice of Standard of Care, regardless of subsequent anti-neoplastic treatment

This description comes directly from the study's public registry record.

Talk to the study team

Novartis Pharmaceuticals  ·  1-888-669-6682  ·  novartis.email@novartis.com

Novartis Pharmaceuticals  ·  +41613241111

Always discuss trial participation with your own doctor first.

Locations (81)

VA Greater LA Healthcare SystemLos Angeles, California, United StatesRecruiting
VA Palo Alto Health Care SystemPalo Alto, California, United StatesRecruiting
Stanford University Medical CenterPalo Alto, California, United StatesRecruiting
Sansum ClinicSanta Barbara, California, United StatesRecruiting
Saint Johns Cancer InstituteSanta Monica, California, United StatesRecruiting
Hartford HospitalHartford, Connecticut, United StatesRecruiting
AdventHealthOrlando, Florida, United StatesRecruiting
University Cancer and Blood Center LLCAthens, Georgia, United StatesRecruiting
Emory UniversityAtlanta, Georgia, United StatesRecruiting
Indiana UniversityIndianapolis, Indiana, United StatesRecruiting
University of Kansas HospitalKansas City, Kansas, United StatesRecruiting
East Jefferson HospitalMetairie, Louisiana, United StatesRecruiting

+ 69 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT06780670