Condition: Pregnancy Complications · Pre-Eclampsia · Growth Retardation, Intrauterine · Sponsor: Centre Hospitalier Universitaire de Nīmes
Pregnancy increases the risk of thrombosis. Placenta-mediated diseases are a risk factor for cardiovascular pathologies and can lead to maternal-fetal morbidity and mortality. It is essential to understand the cellular and molecular mechanisms of dysfunctions at the vascular-placental interface so that systemic vascular risk can be characterized and, ultimately, screened for, on the basis of new markers (targeted preventive management). Deregulated autophagy could be the starting point for cell death by apoptosis or necrosis leading to complications. The pathophysiological mechanisms involved in trophoblast apoptosis are incompletely described. This project follows on from the GrossAuTop-1 study, which investigated the intra- and inter-individual variability of autophagy and apoptosis activities in women during pregnancy. The aim of this project is to study autophagy and apoptosis activities specifically in women developing a placental vascular complication during pregnancy.
This description comes directly from the study's public registry record.
Sylvie BOUVIER, Dr. · +334.66.68.32.11 · sylvie.bouvier@chu-nimes.fr
Anissa MEGZARI · +334 66 68 42 36 · drc@chu-nimes.fr
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| Nimes University Hospital | Nîmes, France | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06779916