Condition: Brain Edema Caused by Drugs · Cerebral Oxygenation · Sponsor: Georgia Tsaousi
The brain is a metabolic active organ with constant energy demands. Brain oxygen supply is secured via cerebral circulation. Brain tumor surgery is commonly associated with the tumor's underlying pathophysiology including brain swelling or edema. During craniotomy for brain tumor resection maintenance of cerebral hemodynamic stability is of paramount importance. Neuroinflammation is also a normal response to trauma, such as in the case of brain tumor surgery. The role of neuroinflammation in postoperative brain function is well documented and the aim is to limit it through an appropriate anesthetic approach. Anesthetic agents used during surgery affect brain homeostasis. The anesthetic agent of choice for neurosurgery should deliver smooth and hemodynamically stable anesthesia, good operating conditions, and allow early neurological assessment. Also, the ideal anesthetic agent should preserve cerebral perfusion and neuroprotection. The two most common categories of anesthetic agents used nowadays for elective craniotomy are intravenous and inhalational agents. Propofol is the intravenous anesthetic agent of choice. The action of propofol involves a positive modulation of the inhibitory function of the neurotransmitter gamma-aminobutyric acid (GABA). Propofol causes a decrease in cerebral metabolic rate (CMR), intracranial pressure (ICP), cerebral perfusion pressure (CPP), and cerebral blood flow (CBF). It also is known for its antiemetic properties. Volatile agents common…
This description comes directly from the study's public registry record.
Georgia Tsaousi, Professor · +302310994855 · tsaousig@otenet.gr
Eleni Chatsiou, MD · +306979314710 · eleni.chatsiou@gmail.com
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| AHEPA University Hospital | Thessaloniki, Greece | Recruiting |
| Aristotle University of Thessaloniki | Thessaloniki, Greece | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06779890