● Recruiting

A Study of CLSP-1025 in Adult Patients With Solid Tumors That Harbor the p53 R175H Mutation

Condition: Advanced Solid Tumor · Unresectable Solid Tumor · Metastatic Solid Tumor · Sponsor: Clasp Therapeutics, Inc.

PhasePhase 1

Planned participants90

Who can joinAll sexes, 18 Years to no upper limit

Healthy volunteersNo

About this study

Phase 1 dose escalation and expansion study of CLSP-1025, a first-in-class HLA-A\*02:01 specific T cell engager (TCE) targeting solid tumors that harbor the p53 R175H mutation.

This description comes directly from the study's public registry record.

Talk to the study team

Lauren Harshman, MD · +1-617-812-1431 · LHarshman@clasptx.com

Always discuss trial participation with your own doctor first.

Locations (21)

HonorHealth Research Institute	Scottsdale, Arizona, United States	Recruiting
The University of Arizona Cancer Center	Tucson, Arizona, United States	Recruiting
USC - Norris Comprehensive Cancer Center	Los Angeles, California, United States	Recruiting
University of California Davis Comprehensive Cancer Center	Sacramento, California, United States	Recruiting
University of California San Francisco	San Francisco, California, United States	Recruiting
University of Miami - Sylvester Comprehensive Cancer Center	Miami, Florida, United States	Recruiting
The University of Chicago Comprehensive Cancer Center	Chicago, Illinois, United States	Recruiting
University of Kentucky Markey Cancer Center	Lexington, Kentucky, United States	Recruiting
Johns Hopkins - Sidney Kimmel Comprehensive Cancer Center	Baltimore, Maryland, United States	Recruiting
Hackensack University Medical Center	Hackensack, New Jersey, United States	Recruiting
NYU Langone Health	New York, New York, United States	Recruiting
Memorial Sloan Kettering Cancer Center	New York, New York, United States	Recruiting

+ 9 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT06778863