Condition: Sexually Transmitted Infection (STI) Prevention · Antibiotic Prophylaxis · Antibiotic Resistance, Bacterial · Sponsor: University College, London
The goal of this observational study is to understand the risk of antibiotic resistance and changes in the human microbiome (bacteria that live inside and on us), if people use antibiotics to prevent sexually transmitted infections (STI prophylaxis, doxycycline post-exposure prophylaxis, or 'doxyPEP'). The study will assess how easy and acceptable it is to find antibiotic resistance and microbiome changes in the throats and guts of men-who-have-sex-with-men (MSM) who use STI prophylaxis. The study will recruit 108 MSM who are using and not using STI prophylaxis. Participants will visit the clinic every 6 months. At each visit, they will provide a throat swab and stool sample, and complete a questionnaire. DNA of the bacteria from the samples will be analysed to identify the bacteria and look for antibiotic resistance.
This description comes directly from the study's public registry record.
Manik Kohli, MBChB MSc · +4420276794466 · m.kohli@ucl.ac.uk
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| Central and North West London NHS Foundation Trust | London, United Kingdom | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06778083