Condition: Cardiac Surgery-associated Acute Kidney Injury · Sponsor: Bayer
Researchers are looking for a better way to treat and prevent cardiac surgery-associated acute kidney injury (CSA-AKI) in people who undergo heart surgeries. CSA-AKI is a common complication in people undergoing heart surgeries, where the kidneys stop working properly. CSA-AKI risk factors include older age and alongside diseases such as kidney disease and diabetes. Longer time with heart-lung machine during heart surgeries also increases the occurrence of CSA-AKI. In this study, researchers want to better understand how CSA-AKI develops (also known as the mechanisms involved in the development of CSA-AKI) in people under heart surgeries, the presence of certain biomarkers in the body, especially with a focus on the early hours and days after the surgery. (A biomarker is a biological molecule found in blood, other body fluids, or tissues that is a sign of a normal or abnormal process, or of a condition or disease.) These biomarkers will be compared in participants who develop CSA-AKI within a week after heart surgery with the participants who do not develop CSA-AKI. The relationship with biomarkers will be determined by examining participants' blood and urine samples before and after surgery. This may help researchers better understand CSA-AKI, identify potential treatment targets and develop possible treatments to prevent CSA-AKI. Participants in this study will be people who have heart surgery already scheduled by their own doctors and have a risk of developing CSA-AKI.…
This description comes directly from the study's public registry record.
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| Herz- und Diabeteszentrum Nordrhein-Westfalen | Bad Oeynhausen, North Rhine-Westphalia, Germany | Recruiting |
| Royal Papworth Hospital NHS Foundation Trust | Royal Papworth Hospital - Cardiac Surgery | Cambridge, Cambridgeshire, United Kingdom | Recruiting |
| Guy's and St Thomas' NHS Foundation Trust | Harefield Hospital - Cardiology | Harefield, Greater London, United Kingdom | Not Yet Recruiting |
| Guy's and St Thomas' NHS Foundation Trust | Guy's & St Thomas' Hospital - Department of Critical Care & Nephrology | London, Greater London, United Kingdom | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06772025