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Study identifier: NCT06771791 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Evaluation of the Efficacy of Oral Immunotherapy With Raw Apple in Patients Allergic to Birch Pollen and Apple: Prospective, Multicenter, Comparative Phase III Study

Condition: Allergies  ·  Sponsor: University Hospital, Strasbourg, France

PhasePhase 3
Planned participants110
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

Apple-birch pollen-food allergy syndrome is particularly common in Northern and Central Europe (70% of patients allergic to birch pollen), and classically induces an oral syndrome that impairs patients' quality of life. Current treatment is based on food avoidance. However, evidence of the efficacy of this treatment is limited (small numbers, lack of validation with a control group, absence of double-blind evaluation of the primary endpoint in a challenge test against placebo). The aim of oral immunotherapy with raw apple is to improve the management of allergic patients by enabling them to acquire tolerance to raw apple and other rosacea.

This description comes directly from the study's public registry record.

Talk to the study team

Anays PIOTIN, Dr  ·  +33 03.69.55.00.49  ·  anays.piotin@chru-strasbourg.fr

Always discuss trial participation with your own doctor first.

Locations (4)

Hôpitaux Universitaires de StrasbourgStrasbourg, France, FranceRecruiting
Chu Jean MinjozBesançon, FranceNot Yet Recruiting
Hopital François Mitterrand Chu DijonDijon, FranceRecruiting
Hopital Maison Blanche Chu ReimsReims, FranceNot Yet Recruiting

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Source record: clinicaltrials.gov/study/NCT06771791