Condition: Non-Muscle Invasive Bladder Urothelial Carcinoma · Recurrent Non-Muscle Invasive Bladder Urothelial Carcinoma · Stage I Bladder Cancer AJCC v8 · Sponsor: National Cancer Institute (NCI)
This phase II trial compares the use of pembrolizumab and radiation therapy to chemotherapy with cisplatin, gemcitabine, 5-fluorouracil or mitomycin-C and radiation therapy for the treatment of non-muscle invasive bladder cancer. Immunotherapy with monoclonal antibodies, such as pembrolizumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Chemotherapy drugs, such as cisplatin, gemcitabine, 5-fluorouracil or mitomycin-C, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Radiation therapy uses high energy x-rays, particles, or radioactive seeds to kill cancer cells and shrink tumors. Giving pembrolizumab with radiation may kill more tumor cells than chemotherapy with radiation therapy in patients with non-muscle invasive bladder cancer.
This description comes directly from the study's public registry record.
Contact details are listed per location below or on the registry record.
Always discuss trial participation with your own doctor first.
| Highlands Oncology Group - Fayetteville | Fayetteville, Arkansas, United States | Recruiting |
| Highlands Oncology Group - Rogers | Rogers, Arkansas, United States | Recruiting |
| Highlands Oncology Group | Springdale, Arkansas, United States | Recruiting |
| AIS Cancer Center at San Joaquin Community Hospital | Bakersfield, California, United States | Recruiting |
| Los Angeles General Medical Center | Los Angeles, California, United States | Recruiting |
| USC / Norris Comprehensive Cancer Center | Los Angeles, California, United States | Recruiting |
| Shaw Cancer Center | Edwards, Colorado, United States | Recruiting |
| Helen F Graham Cancer Center | Newark, Delaware, United States | Recruiting |
| Medical Oncology Hematology Consultants PA | Newark, Delaware, United States | Recruiting |
| UF Health Cancer Institute - Gainesville | Gainesville, Florida, United States | Recruiting |
| Mount Sinai Medical Center | Miami Beach, Florida, United States | Recruiting |
| Grady Health System | Atlanta, Georgia, United States | Recruiting |
+ 122 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT06770582