Condition: ST-segment Elevation Myocardial Infarction (STEMI) · Sponsor: Henan Institute of Cardiovascular Epidemiology
The goal of this clinical trial is to compare the efficacy and safety of intracoronary rhTNK-tPA or Tirofiban in patients with ST-segment elevation myocardial infarction and high thrombus burden. The main questions it aims to answer are: * Is the efficacy of intracoronary rhTNK-tPA non-inferior to intracoronary Tirofiban for the treatment of ST-segment elevation myocardial infarction in patients wiht high thrombus burden? * Does intracoronary rhTNK-tPA increase the incidence of bleeding events? This multicenter RCT study plans to enroll 300 patients, who are randomly divided into two groups: intracoronary rhTNK-tPA or Tirofiban by 1:1. The primary efficacy endpoint was post-PCI corrected TIMI frame count (CTFC). Major adverse events (death, recurrent myocardial infarction, ischemic stroke, or hospitalization for heart failure) were observed at 1 year follow-up.
This description comes directly from the study's public registry record.
You Zhang · +86 37158681037 · 13598019682@126.com
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| Fuwai Central China Cardiovascular Hospital | Zhengzhou, Henan, China | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06769256