Condition: Gastroesophageal Adenocarcinoma · Sponsor: Chia Tai Tianqing Pharmaceutical Group Nanjing Shunxin Pharmaceutical Co., Ltd.
TQB2102 for injection is a novel antibody-coupled drug (ADC) that enhances binding to tumor cell surface HER2 proteins by simultaneously targeting the two non-overlapping epitopes of the HER2 protein, Endothelial Cell Dysfunction 2 (ECD2) and Endothelial Cell Dysfunction 4 (ECD4), increasing HER2 internalization, and then down-regulating the tumor cell surface HER2 proteins more effectively, and doubly blocking the HER2 signaling, to achieve the effects of trastuzumab and Pertuzumab alone and in combination. This is a Phase II study to evaluate the efficacy and safety of TQB2102 for injection in combination with Benmelstobart Injection /Penpulimab Injection ± chemotherapy in patients with unresectable locally advanced, recurrent or metastatic HER2-positive gastroesophageal adenocarcinoma
This description comes directly from the study's public registry record.
Ruihua Xu, Doctor · 86-20-87343468 · ruihxu@163.com
Always discuss trial participation with your own doctor first.
| Fuyang Cancer Hospital | Fuyang, Anhui, China | Not Yet Recruiting |
| Lu'an People's Hospital | Lu'an, Anhui, China | Not Yet Recruiting |
| Maanshan People's Hospital | Maanshan, Anhui, China | Recruiting |
| Peking Union Medical College Hospital | Beijing, Beijing Municipality, China | Not Yet Recruiting |
| The first affiliated hospital of chongqing medical university | Chongqing, Chongqing Municipality, China | Not Yet Recruiting |
| Fujian Cancer Hospital | Fuzhou, Fujian, China | Not Yet Recruiting |
| Gansu Prouincial Cancer Hospital | Lanzhou, Gansu, China | Not Yet Recruiting |
| Gansu Wuwei Tumour Hospital | Wuwei, Gansu, China | Not Yet Recruiting |
| Sun Yat-sen University Cancer Center | Guangzhou, Guangdong, China | Not Yet Recruiting |
| Nanfang Hospital | Guangzhou, Guangdong, China | Not Yet Recruiting |
| Jiangmen Central Hospital | Jiangmen, Guangdong, China | Not Yet Recruiting |
| Meizhou People's Hospital | Meizhou, Guangdong, China | Not Yet Recruiting |
+ 27 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT06767800