Condition: Postmenopausal Osteoporosis · Sponsor: University Hospital, Toulouse
Denosumab (Dmab) is a treatment for postmenopausal osteoporosis. However, its withdrawal is associated with a rebound phenomenon associated with an unexpected increased risk of vertebral fractures. Defining the optimal strategy for Dmab withdrawal is critically needed. Investigator propose an open-label randomized superiority strategy trial to compare the 1-year lumbar densitometric efficacy of biomarkers-driven zoledronate (ZOL) infusion vs standardized ZOL treatment to mitigate rebound phenomenon.
This description comes directly from the study's public registry record.
Yannick DEGBOE, MD · 05 61 77 73 75 · degboe.y@chu-toulouse.fr
Charline DAGUZAN · 05 61 77 84 90 · daguzan.c@chu-toulouse.fr
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| Amiens Hospital | Amiens, France | Recruiting |
| Bordeaux Hospital | Bordeaux, France | Recruiting |
| Cahors Hospital | Cahors, France | Recruiting |
| Dax Hospital | Dax, France | Recruiting |
| Le Mans Hospital | Le Mans, France | Recruiting |
| Lille Hospital | Lille, France | Not Yet Recruiting |
| Limoges Hospital | Limoges, France | Recruiting |
| Marseille Hsopital | Marseille, France | Recruiting |
| Montpellier Hospital | Montpellier, France | Recruiting |
| Nice Hospital | Nice, France | Recruiting |
| Orléans Hospital | Orléans, France | Recruiting |
| Cochin Hospital | Paris, France | Recruiting |
+ 5 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT06767150