← Eichor
Study identifier: NCT06765109 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Neladalkib (NVL-655) for TKI-naive Patients With Advanced ALK-Positive NSCLC

Condition: Non-small Cell Lung Cancer · Anaplastic Lymphoma Kinase-positive  ·  Sponsor: Nuvalent Inc.

PhasePhase 3
Planned participants450
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

Multicenter, randomized, controlled, open-label, Phase 3 study designed to demonstrate that neladalkib (NVL-655) is superior to alectinib in prolonging progression-free survival (PFS) in patients with treatment-naïve, Anaplastic Lymphoma Kinase (ALK) positive, advanced Non-Small Cell Lung Cancer (NSCLC).

This description comes directly from the study's public registry record.

Talk to the study team

Nuvalent Clinical Trials  ·  857-357-7000  ·  clinicaltrials@nuvalent.com

Always discuss trial participation with your own doctor first.

Locations (157)

Palo Verde Hematology OncologyGlendale, Arizona, United StatesRecruiting
Hoag Hospital Newport BeachNewport Beach, California, United StatesRecruiting
University of California, Irvine HealthOrange, California, United StatesRecruiting
Rocky Mountain Cancer CentersBoulder, Colorado, United StatesRecruiting
Sylvester Comprehensive Cancer Center MiamiMiami, Florida, United StatesRecruiting
AdventHealth Cancer InstituteOrlando, Florida, United StatesRecruiting
H Lee Moffitt Cancer Center and Research InstituteTampa, Florida, United StatesRecruiting
Winship Cancer Institute of Emory UniversityAtlanta, Georgia, United StatesRecruiting
Dana-Farber Cancer InstituteBoston, Massachusetts, United StatesRecruiting
Barbara Ann Karmanos Cancer InstituteDetroit, Michigan, United StatesWithdrawn
Washington University Center for Advanced MedicineSt Louis, Missouri, United StatesRecruiting
NYU Langone's Perlmutter Cancer CenterNew York, New York, United StatesRecruiting

+ 145 more locations — full list on the registry record.

Follow this study

Get one email when the public record changes — results posted, or the study's status changes. Nothing else, ever.

We email about this public record only. Unsubscribe anytime with one click. Never medical advice.

Is this your study? This page was generated automatically from the public registry record. Sponsors can claim it — free — to add branding and verified contact routing. Claim this page →

This page is independently generated by Eichor from the public ClinicalTrials.gov record and re-synced daily. It is not the sponsor's official website unless claimed. Nothing here is medical advice; eligibility is always determined by the study team — talk to your own doctor first.

Source record: clinicaltrials.gov/study/NCT06765109