Condition: Acute Lymphoblastic Leukemia ALL · Childhood Leukemia, Acute Lymphoblastic · B Cell Acute Lymphoblastic Leukemia (B-ALL) · Sponsor: Institute of Hematology & Blood Diseases Hospital, China
Building upon the results from the CCCG-ALL-2015, CCCG-ALL-2020 multicenter study cohort, concurrent research findings, and the latest clinical trials, the CCCG-ALL-2025 I/HR-B-ALL is thus developed to further improve the event-free survival (EFS), and overall survival (OS), and quality of life (QoL) of children with intermediate- and high- risk B-cell childhood acute lymphoblastic leukaemia (I/HR-B-ALL), while decreasing adverse reactions and transplantation rates. This trial primarily aims to explore: 1. The efficacy of two randomized Blinatumomab application scheme on I/HR-ALL as determined by MRD negatvitiy rate. 2. The efficacy of modified mini-hyperCVD + Venetoclax in I/HR-ALL cannot afford blinatumomab, in contrast to historical control as determined by MRD negatvitiy rate.
This description comes directly from the study's public registry record.
Jingliao Zhang, MD · +86 22 23909196 · zhangjingliao@ihcams.ac.cn
Xiaofan Zhu, MD · + 86 22 23909001 · xfzhu@ihcams.ac.cn
Always discuss trial participation with your own doctor first.
| Anhui Medical University Second Affiliated Hospital | Hefei, Anhui, China | Not Yet Recruiting |
| Anhui Provincial Children's Hospital | Hefei, Anhui, China | Not Yet Recruiting |
| Fujian Medical University Union Hospital | Fuzhou, Fujian, China | Not Yet Recruiting |
| Guangzhou Women and Children's Medical Center | Guangzhou, Guangdong, China | Not Yet Recruiting |
| Nanfang Hospital, Southern Medical University | Guangzhou, Guangdong, China | Not Yet Recruiting |
| The People's Hospital of Guangxi Zhuang Autonomous Region | Nanning, Guangxi, China | Not Yet Recruiting |
| The Affiliated Hospital of Guizhou Medical University | Guiyang, Guizhou, China | Not Yet Recruiting |
| Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology | Wuhan, Hubei, China | Not Yet Recruiting |
| Union Hospital of Tongji Medical College, Huazhong University of Science and Technology | Wuhan, Hubei, China | Not Yet Recruiting |
| Wuhan Children's Hospital | Wuhan, Hubei, China | Not Yet Recruiting |
| Hunan Children's Hospital | Changsha, Hunan, China | Not Yet Recruiting |
| The Third Xiangya Hospital of the Central South University | Changsha, Hunan, China | Not Yet Recruiting |
+ 15 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT06764238