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Study identifier: NCT06762782 Synced from ClinicalTrials.gov · July 29, 2026
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Clinical Study on the Effectiveness and Safety of Lenvatinib As Adjuvant Treatment for Patients with High-risk Recurrence of Hepatocellular Carcinoma After Surgery

Condition: Hepatocellular Carcinoma (HCC) · Adjuvant Therapy in Patients with Hepatocellular Carcinoma (HCC) At High Risk of Recurrence After Curative Resection or Ablation  ·  Sponsor: The First Affiliated Hospital with Nanjing Medical University

PhasePhase 2
Planned participants276
Who can joinAll sexes, 18 Years to 80 Years
Healthy volunteersNo

About this study

This study is a prospective, randomized, controlled, open, phase II, multicenter clinical study, which aims to evaluate the efficacy and safety of lenvatinib for adjuvant treatment of high-risk recurrent liver cancer after radical surgery. This study is divided into 3 stages: screening period (screening period 28 days), treatment period (up to 12 months, or until any of the following occurs, whichever occurs first: ① The subject has an intolerable toxic reaction and is still not relieved after dose adjustment; ② The subject's first imaging confirmed disease recurrence or withdrew from the study for other reasons), and follow-up period (12 months after the end of treatment). Dosage regimen: Eligible subjects were randomly assigned to the experimental group or the control group in a 2:1 ratio, with surgical method (radical surgery vs ablation) as the stratification factor. The experimental group received lenvatinib treatment, and the control group received best supportive care

This description comes directly from the study's public registry record.

Talk to the study team

Haomin Zhou  ·  86-13645165073  ·  hmzhou@njmu.edu.cn

Always discuss trial participation with your own doctor first.

Locations (1)

The First Affiliated Hospital of Nanjing Medical UniversityNanjing, Jiangsu, ChinaRecruiting

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Source record: clinicaltrials.gov/study/NCT06762782