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Study identifier: NCT06762769 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Isatuximab and Iberdomide as Immunotherapy for High Risk in Smouldering Myeloma

Condition: Smouldering Myeloma  ·  Sponsor: University College, London

PhasePhase 2
Planned participants63
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The study will test a new combination of 3 drugs: Isatuximab (Isa), Iberdomide (Iber) and Dexamethasone (Dex), in patients who have intermediate or high risk smouldering myeloma. Smouldering myeloma is an early form of myeloma which may progress to active multiple myeloma, but at a slow rate. Patients with smouldering myeloma do not usually receive any treatment but will have regular check-ups and observation. Some patients have a diagnosis of smouldering myeloma which has a higher risk of progressing to active myeloma. The study will test if the combination of drugs is effective at preventing or delaying the disease progressing into active multiple myeloma. The study will also test if the combination is tolerated and accepted by patients.

This description comes directly from the study's public registry record.

Talk to the study team

MODIFY Trial Manager  ·  02076799860  ·  ctc.modify@ucl.ac.uk

Always discuss trial participation with your own doctor first.

Locations (2)

Barts Health TrustLondon, United KingdomRecruiting
Nottingham City HospitalNottingham, United KingdomRecruiting

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Source record: clinicaltrials.gov/study/NCT06762769