Condition: Von Willebrand Disease (VWD) · Von Willebrand Disease (VWD), Type 1 · Von Willebrand Disease (VWD), Type 2 · Sponsor: Hemab ApS
This is a first-in-human (FIH), Phase 1/2, 3-part open-label, dose escalation, safety, tolerability, pharmacokinetic (PK), pharmacodynamic (PD), and efficacy study evaluating HMB-002 in participants with VWD. Part A of the study involves a single ascending dose (SAD) regimen design to establish safety, tolerability, PK, and PD effect. In Part B of the study, the safety and tolerability of repeat dosing will be established prior to cohort expansion to explore efficacy. Part C will evaluate the safety, PK, and PD of a single concomitant dose of HMB-002 and factor concentrate with Type 3 VWD or Type 1 VWD with low residual VWF and FVIII who use factor concentrate as prophylaxis.
This description comes directly from the study's public registry record.
Clinical Trials · 080 8304 6409 · clinicaltrials@hemab.com
Always discuss trial participation with your own doctor first.
| Phoenix Children's Hospital | Phoenix, Arizona, United States | Not Yet Recruiting |
| Arkansas Children's Hospital | Little Rock, Arkansas, United States | Not Yet Recruiting |
| Children's Hospital of Los Angeles | Los Angeles, California, United States | Not Yet Recruiting |
| University of Miami Hospital and Clinics, Sylvester Comprehensive Cancer Center | Miami, Florida, United States | Not Yet Recruiting |
| Emory Children's Center | Atlanta, Georgia, United States | Not Yet Recruiting |
| Innovative Hematology, Inc./Indiana Hemophilia and Thrombosis Center | Indianapolis, Indiana, United States | Recruiting |
| Tulane University School of Medicine | New Orleans, Louisiana, United States | Not Yet Recruiting |
| University of Michigan Hospitals, Department of Hemophilia and Coagulation Disorders | Ann Arbor, Michigan, United States | Not Yet Recruiting |
| Mayo Clinic - Rochester | Rochester, Minnesota, United States | Not Yet Recruiting |
| Oregon Health & Science University | Portland, Oregon, United States | Not Yet Recruiting |
| Hemophilia Center of Western Pennsylvania | Pittsburgh, Pennsylvania, United States | Not Yet Recruiting |
| The University of Texas Southwestern Medical Center | Dallas, Texas, United States | Not Yet Recruiting |
+ 13 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT06754852