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Study identifier: NCT06754735 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Trial to Evaluate Cyclical Topical Wound Oxygen Therapy in the Treatment of Chronic Venous Leg Ulcers

Condition: Venous Leg Ulcer (VLU)  ·  Sponsor: AOTI Ltd.

PhasePhase 4
Planned participants212
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The purpose of this study is to evaluate the efficacy, safety and economic benefits of Cyclical Pressure Topical Wound Oxygen (TWO2) Therapy in the treatment of venous leg ulcers. Participants will utilize standard of care (SOC) multilayer compression dressings with an inactive wound contact layer. Following a 2-week run-in period with SOC and after meeting all eligibility criteria, subjects will be randomized in a 1:1 ratio with TWO2 therapy or sham control therapy plus SOC. Participants will enter the intervention period of up to 16-weeks, followed by a long-term follow-up period of 52 weeks post randomization.

This description comes directly from the study's public registry record.

Talk to the study team

Despina Herodotou, MRCPod, DABPMi  ·  1-760-431-4700  ·  despi.herodotou@aotinc.net

Always discuss trial participation with your own doctor first.

Locations (1)

Vascular Institute of New YorkNew York, New York, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT06754735