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Study identifier: NCT06747195 Synced from ClinicalTrials.gov · July 29, 2026
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The Impact of Methylene Blue on the Quality of Recovery in Patients Undergoing Hemorrhoidectomy

Condition: Hemorrhoidectomy · Postoperative Analgesia  ·  Sponsor: Qilu Hospital of Shandong University

PhaseN/A
Planned participants290
Who can joinAll sexes, 18 Years to 65 Years
Healthy volunteersNo

About this study

Classical hemorrhoidectomy is known to be linked with significant postoperative pain, which can result in patient discomfort, extended hospital stays, and increased costs. The Quality of Recovery (QOR) score serves as an objective measure of patient-centered general health status following surgery and anesthesia. The latest version, QOR-15, is known for its time-efficiency, high rate of response, and completion, and has been validated in patients undergoing a range of surgical procedures. Methylene blue (MB) is a water-soluble thiazine dye used to treat various conditions and has been found to have a unique analgesic property through the temporary disruption of anal sensory nerve terminals in patients. Studies conducted in Singapore and China have shown that perianal intradermal injection of MB provides temporary pain relief after hemorrhoidectomy and lateral anal sphincterotomy. However, there is limited published information regarding the impact of MB on the quality of recovery in anorectal surgery. This study aims to evaluate the effect of intradermal MB combined with ropivacaine injection on the quality of recovery for patients undergoing hemorrhoidectomy. Study population Patients with symptomatic third- and fourth-degree hemorrhoids who are undergoing hemorrhoidectomy under spinal anesthesia and are admitted to the hospitals (145 for each group) will be prospectively enrolled in this study. Before participating, all patients or their caregivers will provide written in…

This description comes directly from the study's public registry record.

Talk to the study team

Liang Li, MD  ·  +8618560083822  ·  liliang675@126.com

Teng Li, MD  ·  +8618353086656  ·  litengttkx@163.com

Always discuss trial participation with your own doctor first.

Locations (3)

Heze Hospital of Traditional Chinese MedicineHeze, Shandong, ChinaRecruiting
Qilu hospital of Shandong UniversityJinan, Shandong, ChinaRecruiting
Weifang People's HospitalWeifang, Shandong, ChinaRecruiting

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Source record: clinicaltrials.gov/study/NCT06747195