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Study identifier: NCT06746623 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Nonendoscopic Screening for Barrett's Esophagus in Veterans Without Chronic Reflux

Condition: Obese Patients · Tobacco Use · Veterans  ·  Sponsor: Louis Stokes VA Medical Center

PhaseNA
Planned participants400
Who can joinAll sexes, 40 Years to 85 Years
Healthy volunteersNo

About this study

The veteran population is at increased risk for EAC and its precursor lesion, Barrett's esophagus (BE), due to increased prevalence of disease risk factors compared to the general population. BE is traditionally diagnosed only when patients undergo endoscopy with biopsies. However, due to the high cost of endoscopy and the lack of studies proving efficacy of screening, endoscopy to screen for BE is not routinely recommended. A simpler screening procedure similar to a pap smear would be an ideal way to sample the esophageal tissue for cancer and its precursor condition, BE. This study proposes a non-endoscopic detection method administered in outpatient offices which would increase subsequent endoscopic detection of BE. The study team will be enrolling veterans who do not have history of gastroesophageal reflux but have multiple risk factors for esophageal adenocarcinoma.

This description comes directly from the study's public registry record.

Talk to the study team

Katarina B. Greer, MD/MS  ·  216-791-3800  ·  katarina.greer@va.gov

Lauren H. Hricik, BA  ·  (216) 791-3800  ·  lauren.hricik@va.gov

Always discuss trial participation with your own doctor first.

Locations (1)

VA Northeast Ohio Healthcare SystemCleveland, Ohio, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT06746623