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Study identifier: NCT06744413 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Prehabilitation to Improve Heart Rate Variability (PRIME)

Condition: Cancer Surgery  ·  Sponsor: Università Vita-Salute San Raffaele

PhaseNA
Planned participants600
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

Cancer patients require chronic management and care. For those individuals living with cancer, a comprehensive approach that acknowledges the interdisciplinary nature of their condition can help guide appropriate care strategies and support their overall well-being. Approximately 45% of patients diagnosed with cancer undergo surgery to remove their tumor. Despite the advancements in surgical techniques, anesthesia, and perioperative care, major cancer surgeries still pose a significant challenge leading to a considerable decline in physiological and functional capacity. Traditionally, efforts focused on postoperative rehabilitation to enhance recovery. Recently, prehabilitation, a form of rehabilitation which aims to improve functional capacity before surgery, has gained attention for its potential benefits in improving surgical outcomes. However, prehabilitation lacks objective assessment measures to evaluate its effectiveness. Developing validated outcome measures is essential to enhance the impact of prehabilitation on surgical outcomes and long-term care for cancer patients. Heart rate variability (HRV) is a physiological parameter that measures the variation in time intervals between consecutive heartbeats, reflecting the autonomic nervous system activity which might serve as a valuable solution for objective outcome measures in evaluating the effectiveness of prehabilitation for cancer patients, providing an objective tool to assess and monitor physiological response to…

This description comes directly from the study's public registry record.

Talk to the study team

Fabio Guarracino, Dr  ·  +393281652528  ·  f.guarracino@ao-pisa.toscana.it

Always discuss trial participation with your own doctor first.

Locations (4)

Azienda Ospedaliero Universitaria Policlinico San Marco di CataniaCatania, ItalyActive Not Recruiting
Università di FoggiaFoggia, ItalyRecruiting
IRCCS Ospedale San RaffaeleMilan, ItalyRecruiting
Azienda Ospedaliero Universitaria PisanaPisa, ItalyRecruiting

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Source record: clinicaltrials.gov/study/NCT06744413