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Study identifier: NCT06743126 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

SUPRAME-ACTengine® IMA203 vs. Investigator's Choice of Treatment in Previously Treated, Unresectable or Metastatic Cutaneous Melanoma

Condition: Melanoma, Cutaneous Malignant  ·  Sponsor: Immatics US, Inc.

PhasePhase 3
Planned participants360
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This clinical trial is a prospective, multicenter, open-label, randomized, actively controlled, parallel-group Phase 3 clinical trial to evaluate the efficacy, safety and tolerability of treatment with IMA203 administered at the recommended phase 2 dose versus investigator's choice of treatment in patients with previously treated, unresectable or metastatic cutaneous melanoma. For patients interested in additional information on how to participate, please follow this link: https://mytomorrows.com/trials/suprame/en-us/

This description comes directly from the study's public registry record.

Talk to the study team

Immatics US, Inc.  ·  +1 346 204-5400  ·  ctgovinquiries@immatics.com

Always discuss trial participation with your own doctor first.

Locations (66)

Mayo ClinicPhoenix, Arizona, United StatesRecruiting
Honor Health Research InstituteScottsdale, Arizona, United StatesRecruiting
City of Hope National Medical CenterDuarte, California, United StatesRecruiting
UC San Diego Moores Cancer CenterLa Jolla, California, United StatesRecruiting
UCLA Hematology/OncologyLos Angeles, California, United StatesRecruiting
UCSF Helen Diller Family Comprehensive Cancer CenterSan Francisco, California, United StatesRecruiting
Stanford Cancer CenterStanford, California, United StatesRecruiting
University of Colorado, Anschutz Medical CampusAurora, Colorado, United StatesRecruiting
Yale Cancer CenterNew Haven, Connecticut, United StatesRecruiting
Mayo Clinic FloridaJacksonville, Florida, United StatesActive Not Recruiting
University of Miami - Sylvester Comprehensive Cancer CenteMiami, Florida, United StatesRecruiting
Moffitt Cancer CenterTampa, Florida, United StatesRecruiting

+ 54 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT06743126